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Reproductive Biomedicine
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Volume 16, Issue 6 (Jun 2018)
IJRM 2018, 16(6): 417-420 |
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Yousefi Z, Khalilifar H, Jafarian A H, Davachi B, Mousavi Seresh L, Babapour N, et al . Granulosa-cell tumor after ovarian stimulation: A case report. IJRM 2018; 16 (6) :417-420
URL: http://ijrm.ir/article-1-1138-en.html
URL: http://ijrm.ir/article-1-1138-en.html
Zohreh Yousefi1 
, Hekmat Khalilifar2 , Amir Hosein Jafarian3 , Behrouz Davachi4 , Leila Mousavi Seresh5 , Nooshin Babapour1 , Laya Shirinzadeh * 
6, Mina Baradaran1
, Hekmat Khalilifar2 , Amir Hosein Jafarian3 , Behrouz Davachi4 , Leila Mousavi Seresh5 , Nooshin Babapour1 , Laya Shirinzadeh * 6, Mina Baradaran1
1- Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Kosar IVF Center, Mashhad, Iran
3- Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6- Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sabalanmountain@yahoo.com
2- Kosar IVF Center, Mashhad, Iran
3- Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6- Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , sabalanmountain@yahoo.com
Abstract: (5364 Views)
Background: Ovarian superovulation and increased follicle-stimulating hormone concentration for infertility treatment may be the risk factors of developed granulosa-cell tumor. The aim of this report is to introduce a case of granulosa-cell tumor which was discovered after ovarian stimulation.
Case: A 31-yr-old woman with clinical presentation of massive abdominal distention was referred to the gynecology and oncology department of an academic hospital, Mashhad University of Medical Sciences in Aug 2017. She had the history of secondary infertility and was undergoing In Vitro Fertilization protocol and ovarian stimulation, but, the cycle was canceled. The patient suffered from gradual abdominal distention one month after the end of IVF procedure despite pregnancy failure. 2-3 months after management of the ovarian hyperstimulation syndrome, investigation revealed large ovarian mass and increased tumor marker inhibin. Exploratory laparotomy was performed and revealed stage III ovarian cancer. The final pathology report indicated juvenile granulosa cell tumor. So, optimal surgical staging and cytoreductive surgery without fertility preserving were perfumed. Chemotherapy was recommended due to the advanced stage of ovarian cancer. Unfortunately, she experienced metastatic diseases in pelvic and abdomen in less than six months; and currently is receiving the second and third line chemotherapy.
Conclusion: Persistent ovarian enlargement or ascites during or after infertility treatment should be carefully considered and managed
Case: A 31-yr-old woman with clinical presentation of massive abdominal distention was referred to the gynecology and oncology department of an academic hospital, Mashhad University of Medical Sciences in Aug 2017. She had the history of secondary infertility and was undergoing In Vitro Fertilization protocol and ovarian stimulation, but, the cycle was canceled. The patient suffered from gradual abdominal distention one month after the end of IVF procedure despite pregnancy failure. 2-3 months after management of the ovarian hyperstimulation syndrome, investigation revealed large ovarian mass and increased tumor marker inhibin. Exploratory laparotomy was performed and revealed stage III ovarian cancer. The final pathology report indicated juvenile granulosa cell tumor. So, optimal surgical staging and cytoreductive surgery without fertility preserving were perfumed. Chemotherapy was recommended due to the advanced stage of ovarian cancer. Unfortunately, she experienced metastatic diseases in pelvic and abdomen in less than six months; and currently is receiving the second and third line chemotherapy.
Conclusion: Persistent ovarian enlargement or ascites during or after infertility treatment should be carefully considered and managed
Type of Study: Short Research Reports |
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