Volume 16, Issue 7 (July 2018)                   IJRM 2018, 16(7): 443-446 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mohseni M, Mollaei H R, Arabzadeh S A, Mirshekari T R, Ghorbani P. Frequency of cytomegalovirus in fertile and infertile men, referring to Afzalipour Hospital IVF Research Center, Kerman, IRAN: A case-control study. IJRM 2018; 16 (7) :443-446
URL: http://ijrm.ir/article-1-1168-en.html
Frequency of cytomegalovirus in fertile and infertile men, referring to Afzalipour Hospital IVF Research Center, Kerman, IRAN: A case-control study
Majid Mohseni1 , Hamid Reza Mollaei * 2, Seyed Alimohammad Arabzadeh1 , Tooraj Reza Mirshekari3 , Peyman Ghorbani1
1- Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran. , hamid2008kmu@gmail.com
3- Afzalipour In Vitro Fertilization Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (3176 Views)
Background: Cytomegalovirus (CMV) virus can hide in urinary genital tract cells and affect male infertility disorders.
Objective: To evaluate frequency of CMV in the semen samples of men with infertility problems referring to a in vitro fertilization (IVF) center in Kerman, Iran and its association with the parameters of semen.
Materials and Methods: In this case-control study, Real time polymerase chain reaction test was performed for detection of human cytomegalovirus in 100 fertile men compared to 100 infertile men referred to the IVF center of Afzalipour Hospital, Kerman, Iran.
Results: Out of 200 samples, 30 samples (15%) were positive for CMV DNA virus (23/100 men (23%) in case group and 7/100 men (7%) in the control group). Sperm counts and motility in the control group were more than the case group (p˂0.0001). There was a significant relationship between the prevalence of CMV infection and male infertility (p˂0.001).
Conclusion: Our finding showed that, prevalence of CMV infection was higher in infertile men compared to fertile men and CMV infection can be considered as an important part of male infertility. So; antiviral treatment of positive cases can be effective in improving sperm quality and successful IVF. The relationship between CMV infection in semen and infertility was obtained in previous studies and was confirmed by our study.
Keywords: Infertility, Cytomegalovirus, In vitro fertilization, Real time PCR
Full-Text [PDF 404 kb]   (868 Downloads) |   |   Full-Text (HTML)  (586 Views)  
Type of Study: Original Article |
References
1. Moretti E, Figura N, Campagna MS, Iacoponi F, Gonnelli S, Collodel G. Infectious Burden and Semen Parameters. Urology 2017; 100: 90-96. [DOI:10.1016/j.urology.2016.10.032]
2. Ford WC. Comments on the release of the 5th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. Asian J Androl 2010; 12: 59-63. [DOI:10.1038/aja.2008.57]
3. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010;16: 231-245. [DOI:10.1093/humupd/dmp048]
4. Greil AL, Slauson‐Blevins K, McQuillan J. The experience of infertility: a review of recent literature. Sociol Health Illn 2010; 32: 140-162. [DOI:10.1111/j.1467-9566.2009.01213.x]
5. Garolla A, Pizzol D, Bertoldo A, Menegazzo M, Barzon L, Foresta C. Sperm viral infection and male infertility: focus on HBV, HCV, HIV, HPV, HSV, HCMV, and AAV. J Reprod Immunol 2013; 100: 20-29. [DOI:10.1016/j.jri.2013.03.004]
6. Eggert-Kruse W, Reuland M, Johannsen W, Strowitzki T, Schlehofer JR. Cytomegalovirus (CMV) infection-related to male and/or female infertility factors? Fertil Steril 2009; 91: 67-82. [DOI:10.1016/j.fertnstert.2007.11.014]
7. Kling C, Kabelitz D. HCMV seroprevalence in couples under infertility treatment. Arch Gynecol Obstet 2015; 292: 439-443. [DOI:10.1007/s00404-015-3640-2]
8. Monavari SH, Vaziri MS, Khalili M, Shamsi-Shahrabadi M, Keyvani H, Mollaei H, et al. Asymptomatic seminal infection of herpes simplex virus: impact on male infertility. J Biomed Res 2013; 27: 56-61.
9. Neofytou E, Sourvinos G, Asmarianaki M, Spandidos DA, Makrigiannakis A. Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters. Fertil Steril 2009; 91: 2487-2494. [DOI:10.1016/j.fertnstert.2008.03.074]
10. World Health Organisation. WHO laboratory manual for the examination and processing of human semen. 5th Ed. WHO Press; Switzerland, 2010
11. Baghdadi Kh, Tafvizi F, Hayati Roodbari N. Molecular detection of HCMV and investigation of Its relationship with quality of sperm parameters in male infertility. Electronic J Biol 2016; 10: 312-320.
12. Habibi M, Bahrami A, Morteza A, Sadighi Gilani MA, Hassanzadeh G, Ghadami M, et al. Study of cytomegalovirus infection in idiopathic infertility men referred to Shariati hospital, Tehran, Iran. Iran J Reprod Med 2014; 12: 151-154.
13. Witz CA, Duan Y, Burns WN, Atherton SS, Schenken RS. Is there a risk of cytomegalovirus transmission during in vitro fertilization with donated oocytes? Fertil Steril 1999; 71: 302-307. [DOI:10.1016/S0015-0282(98)00433-6]
14. Yang YS, Ho HN, Chen HF, Chen SU, Shen CY, Chang SF, et al. Cytomegalovirus infection and viral shedding in the genital tract of infertile couples. J Med Virol 1995; 45: 179-182. [DOI:10.1002/jmv.1890450212]
15. Ozbek SM, Ozbek A, Yavuz MS. Detection of human cytomegalovirus and Epstein-Barr Virus in symptomatic and asymptomatic apical periodontitis lesions by real-time PCR. Med Oral Patol Oral Cir Bucal 2013; 18: 811-816. [DOI:10.4317/medoral.18905]
16. Dejucq N, Jegou B. Viruses in the mammalian male genital tract and their effects on the reproductive system. Microbiol Mol Biol Rev 2001; 65: 208-231. [DOI:10.1128/MMBR.65.2.208-231.2001]
17. Naumenko VA, Tyulenev YA, Yakovenko SA, Kurilo LF, Shileyko LV, Segal AS, et al. Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture. Herpesviridae 2011; 2: 7-14. [DOI:10.1186/2042-4280-2-7]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb