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JNFS 2021, 6(1): 31-42 |
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Gheflati A, Mirjalili S A M, Kaviani M K, Salehi-Abargouei A, Hosseini-Marnani E, Nadjarzadeh A. Effects of Vitamin D Supplementation on Semen Quality and Reproductive Hormones in Patients with Asthenozoospermia: A Randomized Double-Blind Placebo-Controlled Clinical Trial. JNFS 2021; 6 (1) :31-42
URL: http://jnfs.ssu.ac.ir/article-1-266-en.html
URL: http://jnfs.ssu.ac.ir/article-1-266-en.html
Alireza Gheflati 
, Seyed Ali Mohamad Mirjalili , Mojtaba Kaviani Kaviani , Amin Salehi-Abargouei , Elham Hosseini-Marnani , Azadeh Nadjarzadeh *
, Seyed Ali Mohamad Mirjalili , Mojtaba Kaviani Kaviani , Amin Salehi-Abargouei , Elham Hosseini-Marnani , Azadeh Nadjarzadeh *
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (2282 Views)
Background: Animal models and observational studies have suggested a favorable role of vitamin D in male reproduction. However, randomized clinical trials investigating the effect of vitamin D supplementation on male fertility are limited. Therefore, this study aimed to examine the effect of vitamin D supplementation on semen quality, reproductive hormones, and anthropometric measurements in vitamin D deficient males with Asthenozoospermia. Methods: Forty-four males with infertility were randomly assigned to the vitamin D group (DG, supplemented with 9 pearls of vitamin D containing 50000 IU vitamin D3 once a week for 12 weeks) and placebo group (PG, received 9 pearls of placebo once a week for 12 weeks). Semen quality markers (sperm count, morphology, sperm motility, semen volume), total testosterone, sexual hormone binding globulin (SHBG), free androgen index (FAI), and anthropometric measurements (weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist to hip ratio (WHR) were measured at the baseline and the end of the study. Results: Serum 25-OH-D levels were significantly higher in the DG compared with the PG. In a multivariate adjusted model, WC significantly decreased in the DG in comparison to the CG (-0.90 ± 0.67 cm VS 0.49 ± 0.38 cm). A marginally-significant increase was observed after vitamin D supplementation for SHBG compared to the baseline value in DG (11.69 ± 5.79, P = 0.05). Compared to the baseline value, sperm immotile was decreased after vitamin D supplementation in the DG (-12.35 ± 5.13, P = 0.02). However, no statistical significant differences were observed in the semen quality markers (sperm count, morphology, motility, and volume), total testosterone, free androgen index, and other anthropometric values. Conclusions: Vitamin D supplementation did not improve semen quality markers, reproductive hormones, and other anthropometric measurements in vitamin D–deficient infertile men compared to the control group.
Type of article: orginal article |
Subject:
public specific
Received: 2019/06/10 | Published: 2017/11/15 | ePublished: 2017/11/15
Received: 2019/06/10 | Published: 2017/11/15 | ePublished: 2017/11/15
References
1. Aadahl M & JØrgensen T 2003. Validation of a new self-report instrument for measuring physical activity. Medicine and Science in Sports and Exercise. 35 (7): 1196-1202.
2. Alzoubi A, et al. 2017. Nomalization of serum vitamin D improves semen mortility parameters in patients with igiopathic male inertility. Acta Endocrinologica (Bucharest). 13 (2): 180.
3. Anagnostis P, Karras S & Goulis DG 2013. Vitamin D in human reproduction: a narrative review. International Journal of Clinical Practice. 67 (3): 225-235.
4. Aquila S, et al. 2009. Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) regulates different aspects of human sperm biology and metabolism. Reproductive Biology and Endocrinology. 7 (1): 140.
5. Bikle D 2009. Nonclassic actions of vitamin D. Journal of Clinical Endocrinology & Metabolism. 94 (1): 26-34.
6. Blomberg Jensen M, et al. 2011. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Human Reproduction. 26 (6): 1307-1317.
7. Blomberg Jensen M, Lawaetz JG, Petersen JH, Juul A & Jørgensen N 2017a. Effects of vitamin D supplementation on semen quality, reproductive hormones and live birth rate: a randomized clinical trial. Journal of Clinical Endocrinology & Metabolism.
8. Blomberg Jensen M, Lawaetz JG, Petersen JH, Juul A & Jørgensen N 2017b. Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial. The Journal of Clinical Endocrinology & Metabolism. 103 (3): 870-881.
9. Blomberg Jensen M, et al. 2010. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction. 25 (5): 1303-1311.
10. Boisen IM, et al. 2017. Possible influence of vitamin D on male reproduction. Journal of Steroid Biochemistry and Molecular Biology. 173: 215-222.
11. Bouillon R, et al. 2008. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews. 29 (6): 726-776.
12. Carlsen E, Swan SH, Petersen JH & Skakkebæk NE 2005. Longitudinal changes in semen parameters in young Danish men from the Copenhagen area. Human Reproduction. 20 (4): 942-949.
13. Chua M, et al. 2013. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta‐analysis. Andrology. 1 (5): 749-757.
14. Colombini A, et al. 2013. Relationship between vitamin D receptor gene (VDR) polymorphisms, vitamin D status, osteoarthritis and intervertebral disc degeneration. Journal of Steroid Biochemistry and Molecular Biology. 138: 24-40.
15. Corbett ST, Hill O & Nangia AK 2006. Vitamin D receptor found in human sperm. Urology. 68 (6): 1345-1349.
16. Dohle G, Smit M & Weber R 2003. Androgens and male fertility. World Journal of Urology. 21 (5): 341-345.
17. Gopalan C & Naidu AN 1972. Nutrition and fertility. Lancet. 300 (7786): 1077-1079.
18. Guzick DS, et al. 2001. Sperm morphology, motility, and concentration in fertile and infertile men. New England Journal of Medicine. 345 (19): 1388-1393.
19. Habib F, Maddy S & Gelly K 1990. Characterisation of receptors for 1, 25-dihydroxyvitamin D3 in the human testis. Journal of Steroid Biochemistry. 35 (2): 195-199.
20. Holick MF 2007. Vitamin D deficiency. New England Journal of Medicine. 357 (3): 266-281.
21. Ingles SA, et al. 1997. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. Journal of the National Cancer Institute. 89 (2): 166-170.
22. Jensen MB 2014. Vitamin D and male reproduction. Nature Reviews Endocrinology. 10 (3): 175.
23. Jungwirth A, et al. 2015. Guidelines on male infertility, European Association of Urology guidelines. Arnhem the Netherlands.
24. Kinuta K, et al. 2000. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 141 (4): 1317-1324.
25. Kong L, Yang Y & Wang G 2007. CatSper and sperm hyperactivation. National Journal of Andrology. 13 (2): 164-167.
26. Kwiecinski G, Petrie G & DeLuca H 1989. Vitamin D is necessary for reproductive functions of the male rat. Journal of Nutrition. 119 (5): 741-744.
27. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR & Heaney RP 2007. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. American Journal of Clinical Nutrition. 85 (6): 1586-1591.
28. Lerchbaum E & Obermayer-Pietsch B 2012a. Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European Journal of Endocrinology. 166 (5): 765-778.
29. Lerchbaum E & Obermayer-Pietsch BR 2012b. Vitamin D and fertility-a systematic review. European Journal of Endocrinology. EJE-11-0984.
30. Monga M, Alexandrescu B, Katz SE, Stein M & Ganiats T 2004. Impact of infertility on quality of life, marital adjustment, and sexual function. Urology. 63 (1): 126-130.
31. Ogunkolade B-W, et al. 2002. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes. 51 (7): 2294-2300.
32. Panth N, Gavarkovs A, Tamez M & Mattei J 2018. The influence of diet on fertility and the implications for public health nutrition in the United States. Frontiers in Public Health. 6.
33. Pilz S, et al. 2011a. Effect of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research. 43 (3): 223.
34. Pilz S, et al. 2011b. Vitamin D, cardiovascular disease and mortality. Clinical Endocrinology. 75 (5): 575-584.
35. Pittas AG, Lau J, Hu FB & Dawson-Hughes B 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. Journal of Clinical Endocrinology & Metabolism. 92 (6): 2017-2029.
36. Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J & Thulstrup AM 2011. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertility and Sterility. 95 (3): 1000-1004.
37. Reproduction EI-MCftESoH, et al. 2016. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. Human Reproduction. 31 (8): 1638-1652.
38. Skakkebaek NE, et al. 2015. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiological Reviews. 96 (1): 55-97.
39. Szodoray P, et al. 2008. The complex role of vitamin D in autoimmune diseases. Scandinavian Journal of Immunology. 68 (3): 261-269.
40. Tiwari A 2009. Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. Investigational Drugs Journal. 12 (6): 381-393.
41. Tüttelmann F, et al. 2012. Combined effects of the variants FSHB− 211G> T and FSHR 2039A> G on male reproductive parameters. Journal of Clinical Endocrinology & Metabolism. 97 (10): 3639-3647.
42. Uhland AM, Kwiecinski GG & DeLuca HF 1992. Normalization of serum calcium restores fertility in vitamin D-deficient male rats. Journal of Nutrition. 122 (6): 1338-1344.
43. Wehr E, Pilz S, Boehm BO, März W & Obermayer‐Pietsch B 2010. Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology. 73 (2): 243-248.
44. World Health Organization 2010a. Examination and processing human semen. Geneva: World Health Organization. 1-287.
45. World Health Organization 2010b. WHO laboratory manual for the examination and processing of human semen.
46. Yamamoto M, Takaba H, Hashimoto J, Miyake K & Mitsuya H 1986. Successful treatment of oligospermic and azoospermic men with alpha 1-blocker and beta-stimulator: new treatment for idiopathic male infertility. Fertility and Sterility. 46 (6): 1162-1164.
47. Závaczki Z, et al. 2003. Magnesium‐orotate supplementation for idiopathic infertile male patients: a randomized, placebo‐controlled clinical pilot study. Magnesium Research. 16 (2): 131-136.
48. Zinaman M, Brown C, Selevan S & Clegg E 2000. Semen quality and human fertility: a prospective study with healthy couples. Journal of Andrology. 21 (1): 145-153.
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